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Cancer is a terminal disease that needs prompt care palliative. The assessment of the quality of life of cancer patient will help proffer better health and prolongation of life. This study seeks to assess cancer patients’ quality of life as perceived by staff nurses in the University of Benin Teaching Hospital and the Central Hospital,in Benin city,
Edo state,Nigeria.The study adopted the descriptive cross sectional research design and a simple random sampling technique was used to select 300 staff nurses in the various
institutions. A 40-item well-structured questionnaire was used as instruments of data collection.The descriptive and inferential statistics were used to analysed the data
generated. The result from the study showed that the respondents had low level of knowledge, positive perception of quality of life and the factors outlined that hindered the utilization of quality of life measurement tools were reported positive. Furthermore, there was a significant relationship between the level of education of the nurses and their level of knowledge as P<0.05. The study also revealed significant relationship between knowledge and perception as well as perception between institutions. Therefore, it is recommended that there should be active education of nurses and training on the use of the cancer quality of life and its measurement tools. Quality of life and its measurement tools should be added to nursing curriculum to be taught in schools of nursing and departments of nursing. Furthermore, Quality of life assessment tools should be made available in health institutions.

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